Browsing by Author "Eren, Elif."

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    Determining the anthropometric characteristics of adult male population of Turkey
    (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.) Eren, Elif.; Ekşioğlu, Mahmut.
    Ergonomics briefly can be described as “human-centered” design. Anthropometry, the science of human body measurements, plays a major role in ergonomic design. Thus, designers must be familiar with anthropometric data and their applications so that they can design work systems, machines, equipment, tool, proper sizing of buildings, clothing and consumer products to achieve safe and efficient operations and/or use. Anthropometric data may show variation among nationalities and races. Hence, an anthropometric database is a need for every nation. Although there are a number of studies on the anthropometry of population of Tukey, most of them lack in various aspects to establish a valid and usable anthropometry database for the population of Turkey. Therefore, the main objectives of this study are as folows: (i) to generate an up-to-date anthropometric database of adult male population of Turkey, (ii) to investigate the effects of age and occupation on body dimensions, (iii) to compare the results with past male anthropometric data of Turkey and with other nationalities, and (iv) to investigate the dimensional changes over time. For the purpose, 65 static and dynamic body dimensions were taken from 250 adult males ages from 18 to 70 yrs. Sampling is done in a stratified manner including subjects from seven regions of Turkey. Subjects were divided into two occupational and five age groups. As a result of this study, 65 body measures of adult male population of Turkey were statistically determined. Average stature and weight were found as 171.5 cm and 76.6 kg, respectively. Results also indicate that stature and other vertical body dimensions decreases with age significantly, proving the secular trend. Also, nonmanual group was found significantly heavier than the manual group. A comparison with 1980s male data indicates that, on average, stature increased 3 cm and weight increased 8 kg. The comparison results with other nationalities indicate that anthropometric data of the male population of Turkey, in general, is similar to the some Southern Europeans and Americans in the USA, greater than Southern Asians and lower than Northern Europeans.
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    NLRC3: a new player at the crossroads of inflammasome regulation, cell proliferation and immune tolerance
    (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.) Eren, Elif.; Özören, Nesrin.
    NLR family proteins are cytoplasmic receptors responsible for the regulation of inflammation. Whereas some NLRs such as Cryopyrin form protein complexes recognizing pathogens and activating inflammation called the inflammasome; the function of other NLRs is still to be characterized. NLRC3, one of the less studied members of this family, was found to be a negative regulator of T-cell activation, NFκB pathway and STING-dependent cytokine secretion. In this thesis, we investigate the role of NLRC3 in the regulation of the Cryopyrin inflammasome, in cell proliferation and its possible involvement in immune tolerance mechanisms. By overexpression and knock-down analyses, we identified whether NLRC3 inhibits Cryopyrin-induced IL-1β cleavage and secretion in response to different stimuli. We determined that NLRC3 exerts its suppressive effect downstream of Cryopyrin by interacting with diffused ASC protein and pro-Caspase-1 via their respective CARD domains and thus may disrupt complex assembly. Secondly, potential regulation of stem cell proliferation by NLRC3 was clarified. Nlrc3 was gradually silenced in more proliferative Apc and Apc Kras organoids. Nlrc3 KO primary tissues were generated using CRISPR/Cas9 techniques and organoid formation capacity of Nlrc3 KO, KD and overexpressing cells were measured. Suppression of Nlrc3 expression increased cell proliferation and organoid formation whereas the opposite phenotype was observed in NLRC3 overexpressing cells. We showed that Nlrc3 KO increases the expression of stem cell (Lgr5) and cell cycle (CyclinD1) markers. Finally, we showed that NLRC3 could be involved in immune tolerance mechanisms since it is expressed in cell lines and tissues from these sites. Furthermore, NLRC3 localized in the nucleus, suggesting that it could act as a transcription factor.