A column generation approach for evaluating delivery efficiencies of collimator technologies in IMRT treatment planning
| dc.contributor | Graduate Program in Industrial Engineering. | |
| dc.contributor.advisor | Taşkın, Zeki Caner. | |
| dc.contributor.author | Gören, Merve. | |
| dc.date.accessioned | 2023-03-16T10:28:54Z | |
| dc.date.available | 2023-03-16T10:28:54Z | |
| dc.date.issued | 2014. | |
| dc.description.abstract | Intensity Modulated Radiation Therapy (IMRT) is a form of cancer treatment which delivers radiation beams to the patient from several directions by using a linear accelerator and a collimator. At the leaf sequencing optimization step of the IMRT treatment planning, the intensity matrices are decomposed into a set of deliverable apertures and their associated intensities. Collimator systems used in IMRT can form di erent geometric shapes of apertures depending on their physical capabilities. Hence, comparing the delivery e ciency of di erent collimator technologies is important to determine the value added by the di erent technologies. In this thesis, we compare the e ciency of using regular, rotating and dual multileaf collimator (MLC) systems under di erent combinations of consecutiveness, interdigitation and rectangular constraints and a virtual freeform collimator. We formulate the problem of minimizing total beam-on time (BOT) as a large-scale linear programming problem. To deal with its dimensionality, we propose a column generation approach. Although there exists a general master problem structure, subproblem depends on the used collimator system technology. Therefore, we model each subproblem individually and apply a di erent solution method to each of them. We test our approach on a set of clinical problem instances. Our results indicate that the dual MLC under consecutiveness constraint yields very similar beam-on time as a virtual freeform collimator which can form any possible segment shape by opening or closing each bixel independently. Our approach provides a ranking between other collimator technologies in terms of their delivery e ciencies. | |
| dc.format.extent | 30 cm. | |
| dc.format.pages | xiv, 60 leaves ; | |
| dc.identifier.other | IE 2014 G77 | |
| dc.identifier.uri | https://digitalarchive.library.bogazici.edu.tr/handle/123456789/13337 | |
| dc.publisher | Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014. | |
| dc.subject.lcsh | Radiotherapy. | |
| dc.title | A column generation approach for evaluating delivery efficiencies of collimator technologies in IMRT treatment planning |
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