Multimodal investigation of fMRI and fNIRS derived breath hold BOLD signals with an expanded balloon model

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dc.contributorPh.D. Program in Biomedical Engineering.
dc.contributor.advisorAkın, Ata.
dc.contributor.advisorÖztürk, Cengizhan.
dc.contributor.authorEmir, Uzay Emrah.
dc.date.accessioned2023-03-16T13:17:29Z
dc.date.available2023-03-16T13:17:29Z
dc.date.issued2008.
dc.description.abstractMultimodal investigation of blood oxygenation level-dependent (BOLD) signal, using both functional near infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI), may give further insight to the underlying physiological principles and the detailed transient dynamics of the vascular response. Utilizing a breath hold task (BHT), we measured deoxy-hemoglobin (HbR) and oxy-hemoglobin (HbO) changes via fNIRS and blood oxygen level dependent (BOLD) changes by fMRI. Measurements were taken in four volunteers asynchronously and carefully aligned for comparative analysis. In order to describe the main stimulus in BHT, partial pressure of carbon dioxide (PaCO2) parameter was integrated into the balloon model as the driving function of cerebral blood ow (CBF) which led to the development of an expanded balloon model (EBM). During BHT, the increase in HbR was observed later than the BOLD peak and coincided temporally with its post stimulus undershoot. Further investigation of these transients with PaCO2 integrated balloon model suggests that post stimulus undershoot measured by fMRI is dominated by slow return of cerebral blood volume (CBV). This was con rmed by fNIRS measurements. In addition, BOLD signal decreased with the increase of the initial level of PaCO2 derived from EBM, indicating an e ect of basal CBF level on the BOLD signal. In conclusion, a multimodal approach with an appropriate biophysical model gave a comprehensive description of the hemodynamic response during BHT.|Keywords: Functional near-infrared spectroscopy, Functional magnetic resonance imaging, BOLD signal, Partial pressure of CO2, Balloon model, Post stimulus undershoot.
dc.format.extent30cm.
dc.format.pagesxiv, 84 leaves;
dc.identifier.otherBM 2008 E45 PhD
dc.identifier.urihttps://digitalarchive.library.bogazici.edu.tr/handle/123456789/19146
dc.publisherThesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2008.
dc.relationIncludes appendices.
dc.relationIncludes appendices.
dc.subject.lcshMagnetic resonance imaging.
dc.subject.lcshNear infrared spectroscopy.
dc.subject.lcshCarbon dioxide.
dc.titleMultimodal investigation of fMRI and fNIRS derived breath hold BOLD signals with an expanded balloon model

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