Anti-angiogenesis chemotherapy agents
| dc.contributor | Graduate Program in Chemistry. | |
| dc.contributor.advisor | Sanyal, Rana. | |
| dc.contributor.author | Çıtak, Duygu. | |
| dc.date.accessioned | 2023-03-16T11:01:34Z | |
| dc.date.available | 2023-03-16T11:01:34Z | |
| dc.date.issued | 2010. | |
| dc.description.abstract | Angiogenesis can be explained as the growth of new blood vessels from pre-existing vasculature. It has an important and vital role in growth and development, as well as in wound healing. Anti-angiogenic substances suppress the growth of new blood vessels so prevent nutrients and oxygen needed for the growing of tumor cells. It is proposed that tumor angiogenesis could serve as a potential target for anticancer therapy. Combretastatin (CA-4) is an anti-angiogenesis agent that inhibits the tubulin polymerization. CA-4 exhibits anti-tumor effects through the well-organized therapeutic mechanism of tumor blood supply disabling. By affecting selectively and blocking tumor vasculature, CA-4 reduces the blood supply needed for tumor growth and survival. As a result of oxygen poverty and build-up of tumor metabolic by-products causes the death of the cancer cells within the central core of the tumor. In this thesis, covalent modification of CA-4 has been investigated. Variety of CA-4 analogs which involved blocking the free alcohol group has been synthesized. | |
| dc.format.extent | 30cm. | |
| dc.format.pages | xiii, 57 leaves; | |
| dc.identifier.other | CHEM 2010 C58 | |
| dc.identifier.uri | https://digitalarchive.library.bogazici.edu.tr/handle/123456789/14466 | |
| dc.publisher | Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010. | |
| dc.relation | Includes appendices. | |
| dc.relation | Includes appendices. | |
| dc.subject.lcsh | Neovascularization. | |
| dc.title | Anti-angiogenesis chemotherapy agents |
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