Liposomes encapsulating cosmetic raw materials
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Date
2017.
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Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017.
Abstract
Vesicles are highly ordered self-assemblies consisting of concentric bilayers formed by self-aggregation of amphiphilic building blocks in the presence of water. Their enclosed structures makes them perfect vehicles for studies in many areas from targeted drug delivery to cosmetic raw material encapsulation. For a substance to operate onto the skin e ectively it is necessary to penetrate through stratum corneum, outermost layer of the skin. As vesicles have structures very similar to skin membrane, they have the ability to fuse with skin outer layer. Due to this unique characteristic, usage of vesicles is promoted lately in cosmeceuticals industry. In this study, a novel liposome composition has been introduced by using skin lipids such as ceramides, cholesterols and cholestryl sulfates. E ect of di erent downsizing methods on liposome size and stability is compared. To increase the vesicle stability and keep away possible bacterial infections, a new dispersion media consisting of ethanol has been introduced. Encapsulation e ciencies of the obtained liposomes are investigated with some cosmetic raw materials like laggrin, madecososide and heterosides. These molecules are chosen speci cally for their common therapeutic e ects on skin diseases such as eczema and atopic dermatitis. Filaggrin has been used for the rst time in an encapsulation study with this research.